Arbeit

Meine hauptberufliche Arbeit an der Universitätsmedizin Greifswald

Assoziationsstudien

SHIP

Seit Sommer 2008 besteht der Schwerpunkt meiner Arbeit in der Durchführung und statistischen Auswertung von Assoziationsstudien auf Basis der Genotyp- und Phänotypdaten der Study of Health in Pomerania - SHIP.
Ziel der Arbeit ist es, letztendlich Gene zu finden, die ursächlich zur Anfälligkeit von komplexen Krankheiten beitragen.

Allelotyping

Ein kostengünstigerer Ansatz zur Idenifizierung solcher Krankheitsanfälligkeits-Gene besteht in der Analyse von gepoolter DNA mehrerer Personen. Zur Verwaltung und Auswertung dieser Daten wurde von mir eine Datenbank auf Basis von Caché entwickelt.

 
Ausgewählte Vorträge und Publikationen
Vorträge

Method for a semi-automated low level quality control of a large number of Infinium HumanMethylation450 BeadChips, Seventh Workshop of Genetic Epidemiology (Hannover Medical School / University Hospital Schleswig-Holstein): Shaping Big Data in Precision Medicine and Epidemiology, April 2017, Grainau, Germany

Using Mendelian randomization to assess causality between vitamin D levels and kidney function, Seventh Workshop of Genetic Epidemiology (Hannover Medical School / University Hospital Schleswig-Holstein): Shaping Big Data in Precision Medicine and Epidemiology, April 2017, Grainau, Germany

Genetic Epidemiology in the SHIP Study – an Overview and Technical Challenges, May 2016, Erasmus Medical Center Rotterdam, The Netherlands

On the Tip of Omics, Grainau, Germany: A genome-wide meta-analysis of hyper- and hypothyroidism and thyroid function, Sixth Workshop of Genetic Epidemiology (HelmholtzZentrum münchen): On the Tip of Omics, April 2016, Grainau, Germany

Genome-wide association studies identify RAB38 and HS6ST1 associated with albuminuria in diabetes, Annual Meeting of The American Society of Human Genetics (ASHG), October 2015, Baltimore, USA

Methods for meta-analyzing gene expression probes of different array systems on the example of lipid traits, Fourth Workshop of Genetic Epidemiology: Omics - a magic wor(l)d, May 2014, HelmholtzZentrum münchen / Innsbruck Medical University

Novel Loci of Kidney Function: the CKDGen Consortium, CHARGE investigator meeting, January 2014, Los Angeles, USA

Moderation of the Transcriptomic Discussion Panel, Allergy School on the Place of Omics in the Diagnostic Lab – Update on A&CI Laboratory Methods, Oktober 2013, European Academy of Allergy and Clinical Immunology (EAACI)

A GWAS meta-analysis of circulating levels of IGF-I and IGFBP-3, Dritter Workshop zur Genetischen Epidemiologie: Genetic Variants, Omics, and Individualized Prevention, April 2013, HelmholtzZentrum münchen

A GWAS of structural thyroid parameters (size and goiter), 8. Frühjahrsakademie der Gesellschaft für Genetik: Genetic epidemiology, status quo - where to go, April 2010, HelmholtzZentrum münchen

Genome-wide Association studies using the SHIP cohort, International Workshop: Genome-wide Association Studies, November 2008, Alfried Krupp Wissenschaftskolleg Greifswald

A genome–wide association study to detect susceptibility loci for aggressive periodontitis using pooled DNA samples, International Conference: Target identification and target validation in tumour research, Juni 2008, Alfried Krupp Wissenschaftskolleg Greifswald

Publikationen

Wild P.S., Felix J.F., Schillert A., Teumer A., Chen M.H. et al. Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest. 2017;pii: 84840. doi: 10.1172/JCI84840

Teumer A., Qi Q., Nethander M., Aschard H., Bandinelli S., Beekman M. et al. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 2016;15: 811–24

Pattaro C., Teumer A., Gorski M., Chu A.Y., Li M., Mijatovic V. et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. Nature Publishing Group; 2016;7: 10023

Kasbohm E., Holtfreter B., Völker U., Petersmann A., Samietz S., Biffar R., Völzke H., Meisel P., Kacprowski T., Homuth G., Kocher T., Teumer A. Exome Variant Analysis of Chronic Perio-dontitis in 2 Large Cohort Studies. J Dent Res. SAGE Publications; 2016; 22034516665076

Teumer A., Schurmann C., Schillert A., Schramm K., Ziegler A., Prokisch H. Analyzing Illumina Gene Expression Microarray Data Obtained From Human Whole Blood Cell and Blood Monocyte Samples. Methods Mol Biol. 2016;1368: 85–97

Teumer A., Tin A., Sorice R., Gorski M., Yeo N.C., Chu A.Y. et al. Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes. Diabetes. 2016;65: 803–17

Auer P.L., Teumer A., Schick U., O’Shaughnessy A., Lo K.S., Chami N. et al. Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits. Nat Genet. 2014;46: 629–34

Köttgen A., Albrecht E., Teumer A., Vitart V., Krumsiek J., Hundertmark C. et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013;45: 145–154

Teumer A.; Holtfreter B.; Völker U.; Petersmann A.; Nauck M.; Biffar R.; Völzke H.; Kroemer H.K.; Meisel P.; Homuth G.; Kocher T. Genome-wide association study of chronic periodontitis in a general German population. J Clin Periodontol. 2013 Nov;40(11):977-85

Westra H.J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet. 2013 Oct;45(10):1238-43

Teumer A.; Ernst F.D.; Wiechert A.; Uhr K.; Nauck M.; Petersmann A.; Völzke H.; Völker U.; Homuth G. Comparison of genotyping using pooled DNA samples (allelotyping) and individual genotyping using the affymetrix genome-wide human SNP array 6.0. BMC Genomics. 2013 Jul 26,14:506

Tozzi F.; Teumer A.; Munafò M; Rawal R. et al. A genomewide association study of smoking relapse in four European population-based samples. Psychiatr Genet. 2013 Aug,23(4):143-52

Köttgen, A.; Albrecht, E.; Teumer, A.; Vitart, V.; Krumsiek, J. et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 2013, 45(2), 145-54

Hek, K.; Demirkan, A.; Lahti, J.; Terracciano, A.; Teumer, A. et al. A Genome-Wide Association Study of Depressive Symptoms. Biological Psychiatry, 2013, pii: S0006-3223(12)00897-9

Schurmann, C. et al. Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium. PLoS ONE, 2012, 7(12), e50938

Coviello, A. D. et al. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genetics, 2012, 8(7), e1002805

Rawal, R.; Teumer, A.; Völzke, H.; Wallaschofski, H.; Ittermann, T. et al. Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. Human Molecular Genetics, 2012, 21(14), 3275-82

Pattaro, C.; Köttgen, A.; Teumer, A.; Garnaas, M.; Böger, C. A. et al. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics, 2012, 8(3), e1002584

Zhai, G.; Teumer, A.; Stolk, L.; Perry, J. R. et al. Eight common genetic variants associated with serum DHEAS levels suggests a key role in ageing mechanisms. PLoS Genetics, 2011, 7(4), e1002025

Teumer, A.; Rawal, R.; Homuth, G.; Ernst, F. et al. Genome-wide Association Study Identifies Four Genetic Loci Associated with Thyroid Volume and Goiter Risk The American Journal of Human Genetics, 2011, 88(5):664-73

Kaplan, R. C.; Petersen, A.; Chen, M.; Teumer, A. et al. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. Human Molecular Genetics, 2010, 20(6), 1241-1251

Kolz, M.; Johnson, T.; Sanna, S.; Teumer, A.; Vitart, V. et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genetics, 2009, 5(6), e1000504

 
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20.04.2017

© 2017 Alexander Teumer